PATHOLOGICAL CALCIFICATION OF BLOOD VESSELS, RELATIONSHIP WITH OSTEOGENESIS AND BONE DESTRUCTION, MOLECULAR TARGETS FOR THE SEARCH FOR THERAPEUTIC MOLECULES

Various skeletal, endocrine and cardiovascular disorders are directly or indirectly associated with disturbances in calcium and phosphorus homeostasis, and manifested in bone resorption and ectopic calcification. Recent research shows that signs of osteoporosis are associated with a high incidence of atherosclerotic plaque formation. The article provides a brief review of scientific literature data on the study of the molecular basis of pathological vascular calcification. The general pathogenetic links and targets of the processes of osteogenesis, calcification and osteoporosis are considered, and possible ways of pharmacotherapeutic influence on them are discussed. Analyzing the above-mentioned targets and mechanisms of development of pathological vascular calcification, as well as the close relationship between the processes of calcification and osteoporosis, it is advisable to search for new pharmacotherapy to prevent its development among natural and synthetic compounds in several directions: calcium antagonists; antiosteoporetic agents, as well as agents that increase the synthetic activity of osteoblasts and the expression of inhibitors of vascular calcification; agents that reduce PTH levels; agents that bind elevated levels of phosphate and calcium in the blood; vitamin D and its analogues.