STUDY OF THE COMPOSITION OF ATHEROSCLEROTIC PLAQUES BY NEUTRON ACTIVATION ANALYSIS

Atherosclerosis is one of the most important problems of modern medicine, in which the structure and inner lining of the arteries changes. All these processes lead to a narrowing of the lumen of blood vessels and can lead to acute circulatory disorders. Studying chemical elements directly in vascular tissues allows us to understand the mechanisms of development of cardiovascular diseases, in particular atherosclerosis. The purpose of this study is to study the microelement composition of atherosclerotic plaques at various stages of development of the atherosclerosis process. Neutron activation analysis, which has a number of advantagessuch as high sensitivity, selectivity, and does not require sample decomposition, was used as a research method. According to the developed method, the content of 13 elements in lipid, fibrous, ulcerated and calcific plaques was determined. It has been established that during the progression of atherosclerosis, the content of a number of essential elements changes, the content of calcium, strontium, selenium, zinc and iron increases and the bromine content decreases. It has been suggested that iron plays a role in the progression of atherosclerotic vascular lesions. This study was carried out in accordance with the theme of the innovative project Clinical, biochemical and pathogenetic problems of diseases of the circulatory system (atherocalcinosis of the carotid and iliac arteries), post-Covid neurological, psychiatric, osteoarticular complications, treatment" No. FM-20230414707