Tomoscintigraphy for detecting gastrointestinal and medullary thyroid cancers: first clinical results using radiolabelled monoclonal antibodies against carcinoembryonic antigen.
C. Bercheprofessor and head of nuclear medicine departmentJ.-P. MachDepartment of Internal Medicine, University Hospital (Kantons-spital), Basel, SwitzerlandJ. LumbrosoInstitut Gustave-Roussy and Institut de Recherches de Radiobiologie Clinique, F-94800 Villejuif, FranceCrystal S. Langlaischief of radiation department and director of the Institut de Recherches de Radiobiologie Clinique Ludwig Institute for Cancer Research, 1066 Epalinges, Lausanne, SwitzerlandFlorent AubryDepartment of Internal Medicine, University Hospital (Kantons-spital), Basel, SwitzerlandF. Bucheggerprofessor and head of nuclear medicine departmentS CarrelDepartment of Internal Medicine, University Hospital (Kantons-spital), Basel, SwitzerlandP RougierDepartment of Internal Medicine, University Hospital (Kantons-spital), Basel, SwitzerlandC ParmentierDepartment of Internal Medicine, University Hospital (Kantons-spital), Basel, SwitzerlandM Tubianachief of radiation department and director of the Institut de Recherches de Radiobiologie Clinique Ludwig Institute for Cancer Research, 1066 Epalinges, Lausanne, Switzerland
ABI
Abstract
Transaxial tomoscintigraphy (or single-photon emission computerised tomography) was used to detect secondary deposits of carcinoma in 17 patients who had been injected with iodine-131-labelled monoclonal antibodies against carcinoembryonic antigen. Of 17 tumor sites studied by tomoscintigraphy 16 were detected (sensitivity 94%); five sites had a volume smaller than 10 cm3. Tomoscintigraphy also detected three unknown tumour deposits later confirmed by surgery or radiology. In contrast, when 21 tumour sites in the same patients were studied by rectilinear scintigraphy, only nine tumour sites were detected (sensitivity 43%), of which eight had a volume larger than 50 cm3.
Topics
Identifiers
Citations and references
Cited by 014 references
Metrics — AkademScholar · Coming soon