Synthesis of tritium labeled Boc‐[Nle<sup>11</sup>] ‐substance P<sub>5</sub>‐11
Naoki SasakiInstitute of Natural Substance Chemistry, C.N.R.SR. MichelotInstitute of Natural Substance Chemistry, C.N.R.SJ.L. MorgatBiochemistry Section, Department of Biology, C.E.A. Saclay, Gif-sur-Yvette, FranceRoger GenetBiochemistry Section, Department of Biology, C.E.A. Saclay, Gif-sur-Yvette, FrancePierre PotìerInstitute of Natural Substance Chemistry, C.N.R.S
ABI
Abstract
An optically active, alkynyl analogue of norleucine (Nle), L‐2‐amino‐4‐hexynoic acid (Aha), was substituted for Met in the solution synthesis of the Boc‐protected C ‐terminal heptapeptide analogue of substance P. Treatment of the resulting alkynyl peptide with tritium gas in the presence of 10% Pd/C afforded a Boc‐(Nle 11 )‐substance P 5 ‐11 with a specific radioactivity of 96 Ci/mmol.
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