[Characteristic of oxidative metabolism and microsomal enzyme system of the liver in patients with chronic circulation insufficiency].

Abstract

The examination of 52 patients with circulation insufficiency class II-III (CI) provided evidence on suppressed monooxygenase system of the liver brought by lipid peroxidation (LPO) activation in CI of different etiology. The severity of the above changes was related to CI class. LPO intensification weakens anti-oxidant defense and promotes enhancement of endogenic intoxication. The latter becomes most pronounced in CI of the III degree.

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