A New Neoclerodane Diterpenoid from Scutellaria hematochlora
Abstract
From the aerial parts of Scutellaria hematochlora, a new neoclerodane diterpenoid, hematochloridin (1) was isolated together with acetovanillon, vanillin, apigenin and sitosterol 3-O-glucoside.The structure of the new compound was elucidated by spectral analyses.The genus Scutellaria (Labiatae) has been known to contain neoclerodane and seco-abietane diterpenoids, 1 flavonoids and phenylethanoids. 2 During the course of our studies on the constituents of medicinal plants grown in Uzbekistan Republic, we examined the diterpenic constituents of Scutellaria hematochlora (Uzbek name: Kukamaran) which was used in Uzbekistan Republic as a remedy for allergy. 3From the EtOAc soluble fraction of the methanolic extract of the aerial parts of S. hematochlora, we isolated a new neoclerodane type diterpenoid, hematochloridin (1), together with acetovanillon, 4 vanillin, 5 apigenin 5 and sitosterol 3-O-glucoside. 6This paper describes the structure elucidation of the new compound.Hematochloridin (1), [α] D -15.0 (CHCl 3 ) was obtained as an amorphous powder and the molecular formula was determined as C 2 5 H 3 6 O 7 based on its negative ion high resolution