Synthesis of Cefetamet pivoxil hydrochloride

Abstract

Cefetamet pivoxil hydrochloride belong to the class of orally absorbed prodrug esters which is hydrolyzed to the active parent compound-cefetamet in vivo.This paper describes the preparation of cefetamet pivoxil hydrochloride.Its production process is simple and low cost: 7-amino-3-deacetoxyl-cophalosproanie acid(7-ADCA) used as the starting material,was reacted with the active ester to give cefetamet and then the product cefetamet was esterified with haloalkyacylate.The resulting ester could be converted to its hydrocloride as the final product.

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