Alcohol dehydrogenase 1B and Aldehyde dehydrogenase 2 Polymorphisms in Uzbekistan.
Abstract
The alcohol dehydrogenase 1B (ADH1B) -2 (47His) allele and the aldehyde dehydrogenase 2 (ALDH2) - 2 (487Lys) alleles are seen among some Asian peoples, but rare among other ethnic groups. This study examined the allele frequencies in the Uzbekistan Republic, which is located in Central Asia. Subjects were derived from a case-control study on peptic ulcer disease, which included 161 Uzbeks and 23 Russians. They were enrolled at the Republic Research Center of Emergency Medicine located in the capital, Tashkent City. Genotyping was performed for ADH1B Arg47His and ALDH2 Glu487Lys with a polymerase chain reaction using confronting two-pair primers. The frequency for the ADH1B- 2 allele was similar among cases and controls. The ALDH2 -2 allele was rare in both. Among 161 Uzbeks, the ADH1B -2 allele frequency was 0.286 (95% confidence interval, 0.237-0.338) and for the ALDH2 -2 allele was 0.016 (0.005-0.036), while among the 23 Russians the figures were 0.083 (0.024-0.208) and 0.000 (0.000-0.077), respectively. There were no significant differences in drinking habits among individuals with different genotypes, although the ALDH2 -2-2 genotype was not observed. The present study demonstrated that the ADH1B -2 allele frequency among Uzbeks was closer to that among Caucasians than East Asians, some Uzbeks also demonstrating the ALDH2 -2 allele.