Article

Polymorphism Of Detoxification Genes And Predisposition To The Development Of Parkinson’s Disease In Uzbek Individuals

K. KhalimovaTashkent Medical Academy, Health care MinistryM.M. RaimovaTashkent Medical Academy, Health care MinistryR. MatmurodovTashkent Medical Academy, Health care MinistryKh. A. RasulovaTashkent Medical Academy, Health care MinistryAmina BurnashevaInstitute of Biochemistry, Academy of SciencesYekaterina JmirkoInstitute of Biochemistry, Academy of SciencesRustam MukhamedovInstitute of Biochemistry, Academy of Sciences

European Medical Health and Pharmaceutical Journaljournal2011en

ABI

Abstract

According to our research, Uzbek individuals with Parkinson’s disease have high prevalence of 0/0 polymorphisms of GSTT1 and GSTM1 genes, as well as combinations of GSTT1 (0/0)/GSTM1/(0/0) genotypes. These mutations are associated with an earlier debut of the disease, its mixed form, and rapid rate of progression. Determination of mutations in GSTT1 and GSTM1 genes of xenobiotic detoxification in patients with Parkinson’s disease confirms multifactorial nature of this pathology and the role of the influence of various external factors in the modification of clinical signs of disease and its prognosis.

Topics

Synthesis and Characterization of Heterocyclic Compounds

Identifiers

DOI: 10.12955/emhpj.v2i0.342

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