Effect of phototherapy in phospholipids' composition of membranes of lymphocytes in experimental COPD
Abstract
Introduction: Membrane phospholipids (PL) provide functional integrity of the cells of respiratory tract. Aim: To study of membrane phospholipids9 composition of peripheral blood lymphocytes in the dynamics of phototherapy in rats with experimental COPD. Methods: An experimental COPD was reproduced in 60 white rats under the influence of tobacco smoke. For half of them we used the method of phototherapy of concentrated pulsed light (CPL) at wavelengths from 600 to 800 nm. Phototherapy was carried out daily for 10 days. The control group consisted of 10 healthy rats. To study the phospholipids9 fractions of lymphocytes we used the high-flow horizontal chromatography. Results: In rats with experimental COPD, compared with the control group, phosphatidylcholine (PC) and phosphatidylethanolamine (PE) were reduced by 31,8% (P Conclusion: Exprimental COPD in the rats is accompanied by quantitative changes in the main fractions of phospholipids in the membranes of peripheral blood lymphocytes. Conducting a course of phototherapy by CPL contributes to positive change in membrane phospholipids of these cells.