An Autopsy Confirmed Case of Behavioral Variant Frontotemporal Dementia with Corticobasal Degeneration Pathology
Eun‐Joo KimDepartments of Neurology, Pathology a , PsychiatrySeung Ha ParkDepartments of Neurology, Pathology a , PsychiatryJeong Hee LeeDepartment of Forensic Medicine, Pusan National University School of Medicine, 49 Busandaehak-ro, Mulgeum-eup, Yangsan 626-870, KoreaJae‐Hyeok LeeDepartments of Neurology, Pathology a , PsychiatryYoung Min LeeNuclear Medicine c ,Seong‐Jang KimDepartment of Forensic Medicine, Pusan National University School of Medicine, 49 Busandaehak-ro, Mulgeum-eup, Yangsan 626-870, KoreaJin‐Hong ShinDepartment of Forensic Medicine, Pusan National University School of Medicine, 49 Busandaehak-ro, Mulgeum-eup, Yangsan 626-870, KoreaMyung‐Jun ShinNuclear Medicine c ,Myung Jun LeeNuclear Medicine c ,Jae Woo AhnMemory and Aging Center, University of California San FranciscoSuk SungMemory and Aging Center, University of California San FranciscoDo Youn ParkDepartments of Neurology, Pathology a ,Dae Soo JungDepartment of Forensic Medicine, Pusan National University School of Medicine, 49 Busandaehak-ro, Mulgeum-eup, Yangsan 626-870, KoreaWilliam W. SeeleyAging Center , University of California San FranciscoGi Yeong HuhDepartments of Neurology, Pathology a , Psychiatry
2015en
ABI
Abstract
A 63-year-old man presented with a 1.5-year history of progressive personality changes.Clinical evaluations revealed severe frontal dysfunction and bilateral frontal atrophy/glucose hypometabolism.He was diagnosed as probable behavioral variant frontotemporal dementia.He continued to decline, and died at the age of 66.At autopsy, numerous tau-positive gilial threads and coiled bodies were observed in the white matter.Tau-positive astrocytic plaques and neuronal cytoplasmic inclusions were also seen in cerebral cortices, which were compatible with corticobasal degeneration.
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