Synthesis of Arylstannanes via Palladium‐Catalyzed Decarbonylative Coupling of Aroyl Fluorides
Muzaffar KayumovCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM) Chinese Academy of Sciences Shanghai 201203 People's Republic of ChinaJiannan ZhaoSchool of Life Science and Technology ShanghaiTech University Shanghai 201210 People's Republic of ChinaSharafitdin MirzaakhmedovInstitute of Bioorganic chemistry Academy of Sciences of the Republic of Uzbekistan Tashkent 100125 UzbekistanDong‐Yu WangCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM) Chinese Academy of Sciences Shanghai 201203 People's Republic of ChinaAo ZhangCAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica (SIMM) Chinese Academy of Sciences Shanghai 201203 People's Republic of China
ABI
Abstract
Abstract Aryl stannanes are valuable precursors in organic transformations, but their synthetic methods are limited. Here we present a Pd‐catalyzed decarbonylative stannylation of acid fluorides in the absence of exogenous base. Various aryl stannanes were efficiently prepared from bench‐stable transition metal catalyst and ligand with broad functional group compatibility and substrate scope including natural products and pharmaceuticals. This protocol was also successfully used to a late‐stage diversification of an existing uricosuric drug probenecid . magnified image
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