FP498THE RELATIONSHIP OF ENDOTHELIAL DYSFUNCTION AND RENAL DYSFUNCTION IN PATIENTS WITH DIABETES MELLITUS TYPE 2
Abstract
RESULTS: A total of 74 participants were enrolled in the study. Through RNA sequencing, we found 107 different miRNA expressions between HVs and patients without DN, and 95 different expressions between HVs and patients with DN. Among these differently expressed miRNAs, we found 7 miRNAs uniquely up-regulated in patients with DN compared to HVs, and 1 miRNA highly expressed in patients with DN when compared to those without DN. Biological pathway analysis of 8 miRNAs revealed that these are likely involved in MAPK, integrins in angiogenesis, and AP-1 transcription factor. Moreover, all these miRNAs had significant correlation with amount of albuminuria. CONCLUSIONS: Patients with DN have different profiles of serum exosomal miRNAs when compared to HVs and these miRNAs may be a promising candidates for diagnosis and treatment of DN.