Flash desorption of low‐volatility compounds deposited on a heated solid substrate (90°C) by dripping liquid methanol
Abstract
RATIONALE: Desorption of low-volatility compounds deposited on a solid substrate by dripping a methanol drop was explored. METHODS: Low-volatility compounds such as drugs and explosives were deposited/dried on the substrate at 35°C. After increasing the temperature to 90°C, 5 μL methanol was dripped onto the substrate. The desorbed analytes were ionized by alternating current corona discharge and analyzed by mass spectrometry. RESULTS: Flash desorption for drugs and explosives was observed accompanied by the rapid evaporation of methanol. However, saccharides, fullerene, cholesterol, and gramicidin S were not detected by the present method. CONCLUSIONS: It was suggested that surface-active compounds were desorbed at the peripheral front region of the spreading liquid methanol accompanied by rapid evaporation of methanol.