Toxicity And Anti-Arrhythmic Activity 1- (4-Dimethylaminophenyl Dimethylaminophenyl) -6, 7-Dimethoxy-1,2,3,4 Tetrahydroisoquinoline
Rejepov JumadillaRakhmanova Hilola-Course, Institute Of Plant Chemistry Named After Academician S.Yu. Junusov Of The Academy Of Sciences, Tashkent City, UzbekistanAzamatov AzizJunior Science Of Research Institute Of Plant Chemistry Named After Academician S.Yu. Junusov Of The Academy Of Sciences, Tashkent City, Uzbekistan
ABI
Abstract
The effect of 1 -(-4-dimethylaminophenyl) -6,7-dimethoxy-1,2,3,4tetrahydroisoquinoloin hydrochloride (conditionally -F-24) on antiarrhythmicactivity in simulating calcium chloride arrhythmia, as well as acute toxicity in experiments, was studied on white out bred rats with the intravenous route of administration. It was found that the drug F-24 has a pronounced ant arrhythmic effect. The average effective (ED50) ant arrhythmic dose is 4.8 mg/kg, the ant arrhythmic index is 20.3, which is significantly more than the comparison drugs verapamil and lidocaine.
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