Results of Frequency Analysis Distribution of Polymorphism Rs1800895 592C>A In IL10 Gene among Patients with Chronic Polypoid Rhinosinusitis
Jamolbek Abdukakhorovich DjuraevDoctor of Philosophy, Department of Otolaryngology and Stomatology, Tashkent Medical Academy, Tashkent, Republic of UzbekistanУ.С. ХасановDoctor of medical science Head of Department of Otolaryngology and Stomatology, Tashkent Medical Academy, Tashkent, Republic of UzbekistanVokhidov Ulugbek NuridinovuchShaumarov Azizkhon ZavkievichDoctor of Philosophy, Department of Otalaryngology and Somatology, Tashkent Medical Academy, Tashkent, Republic of Uzbekistan
ABI
Abstract
Introduction: Chronic polyposis rhinosinusitis is a disease characterized by chronic inflammation of the nasal mucosa and sinuses. In the tissues of polyps and intranasal secretions, an increase in the concentration of various inflammatory mediators, in particular interleukins is observed due to an increase in their de novo synthesis by effector cells. The research objective to study the distribution of genotypic forms of the IL10 gene locus and evaluate their role in the development and clinical course of chronic polypoid rhinosinusitis.
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