Evaluation of the hepatoprotective and antioxidant properties of an aqueous extract of plant polyphenols (helichrysum maracandicum)
S AhmedovaNational University of Uzbekistan named after Mirzo Ulugbek, Tashkent 100174, UzbekistanMuzaffar I. AsrarovNational University of Uzbekistan named after Mirzo Ulugbek, Tashkent 100174, Uzbekistan
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Abstract
Abstract This study investigated in vivo and in vitro the effects of helmar 2 polyphenol extracts isolated from the plant Helichrysum maracandicum in the conditions of toxic hepatitis poisoned by carbon dioxide (CCl4) in rats. The experiments were performed on healthy male rats and grouped hepatitis model animals with CCl4. In toxic hepatitis, helmar 2 polyphenol extracts at a dose of 20 mg/kg showed an inhibitory effect on hepatic mitochondrial lipid peroxidation. Evidently, the inhibitory effect of polyphenol extracts on the peroxidation of hepatic mitochondrial lipids was very close to that of the hepatoprotective drug silymarin.
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