Article

Clinical and Neurological Changes in Children with Down Syndrome Based on The Cytogenetic Profile

Saodatkhon Mukhamadkhanovna SalikhovaDepartment of Neurology, Pediatric Neurology and Medical GeneticsTashkent Pediatric Medical Institute, Tashkent, UzbekistanYakutkhon Nabiyevna MadjidovaDepartment of Neurology, Pediatric Neurology and Medical GeneticsTashkent Pediatric Medical Institute, Tashkent, Uzbekistan

International Journal of Medical Science and Clinical Research Studiesjournal2021en

ABI

Abstract

Down syndrome is the most common chromosomal pathology. It occurs when another chromosome appears in the 21st pair as a result of a random mutation. Often, children with Down syndrome (DS) and related disorders have some neurological problems, severe forms of stereotyped behavior. The purpose of this article was to study the neurological conditions of children with DS. Clinical, neurological, studies were performed in 120 children (75 boys, 45 girls) with DS. It was found that in children with trisomy, neurological deficits in the form of speech disorders, fine motor skills of the hand, disorders of the coordination sphere and autonomic dysregulation are more severe than in children with mosaic and translocation types.

Topics

Down syndrome and intellectual disability research Genetics and Neurodevelopmental Disorders Genomic variations and chromosomal abnormalities

Identifiers

DOI: 10.47191/ijmscrs/v1-i7-07

Citations and references

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