Diagnostics of leukemia by biological microchip for analysis of mll translocations
Mohammad Din ARepublican Specialized Scientific and Practical Medical Center of Hematology (RSSPMCH) of the Ministry of Health of the Republic of UzbekistanSultanova Sh.KhRepublican Specialized Scientific and Practical Medical Center of Hematology (RSSPMCH) of the Ministry of Health of the Republic of UzbekistanBoboev K.T.Republican Specialized Scientific and Practical Medical Center of Hematology (RSSPMCH) of the Ministry of Health of the Republic of UzbekistanKarimov Kh.YaRepublican Specialized Scientific and Practical Medical Center of Hematology (RSSPMCH) of the Ministry of Health of the Republic of Uzbekistan
ABI
Abstract
Translocations involving the MLL gene are common in leukemia [1]. MLL plays an important role in the processes of leukemia through the formation of chimeric genes [2, 3], the most frequent of which are MLL-AF4, MLL-ENL, MLL-AF9, MLL-AF10, MLL-ELL, MLL-AF6. Biological microchip research allows for the rapid, accurate and comprehensive detection of MLL gene rearrangements, as well as the precise determination of the fusion point. In this article, we report that biological microarray studies can be used to provide important molecular information that can improve the diagnosis of patients with deukemia. Objective. The role of a biological microchip in the analysis of MLL translocations in leukemia
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