Features of Immunological Status in Children with Chronic Bronchitis
Abstract
Chronic bronchitis in children is manifested by a number of specific and nonspecific immune responses. In children, there are changes in the system of both cellular and humoral immunity, which are characterized by T-cell immunodeficiency. The aim of the study was to assess the state of the immune status in chronic bronchitis in children. To achieve this goal, 60 children aged 7 to 18 years with chronic bronchitis were examined, who were hospitalized in the pulmonology department of the Republican Specialized Scientific and Practical Medical Center of Pediatrics during 2020-2021. During the period of exacerbation of the disease, a significant decrease in the number of leukocytes, the relative and absolute number of lymphocytes was established. Serum immunoglobulins are one of the main indicators of humoral immunity. In children with chronic bronchitis, on the part of humoral immunity, pronounced hypoimmunoglobulinemia, a sharp increase in the level of IgM, IgA and IgG were noted.