COGNITIVE DISORDERS IN PATIENTS MULTIPLE SCLEROSIS
Abstract
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system resulting from the development of autoimmune reactions to myelin proteins, characterized by demyelination and axonal damage to neurons of varying degrees [1, 4].\n\nMS is one of the complex and socially significant problems of modern neurology, which is primarily determined by its prevalence, a steady increase in morbidity, unpredictability of the course, the defeat mainly of young people of working age and frequent disability.\n\nDespite active study, the MS continues to be a problem with many unresolved issues. This concerns not only the origin and essence of the disease, but also its clinic, which, it would seem, has been studied with sufficient completeness [5, 7].\n\nRecently, there has been an intensification of scientific research devoted to the study of neurodegeneration in MS. It is believed that it is degenerative changes that underlie the progression of irreversible disorders leading to permanent disability. The most striking manifestations of the neurodegenerative process in MS are considered to be the increase in non-reversible neurological disorders (especially neuropsychological) and progressive atrophic changes according to magnetic resonance imaging (MRI).\n\nCognitive impairment in MS has been noted by many researchers. However, information about their frequency, severity in the clinical picture of the disease is contradictory. In the domestic literature, there are no comprehensive studies on the qualitative and quantitative neuropsychological analysis of cognitive disorders. There is no consensus on the factors influencing the development of cognitive dysfunction in MS.