ERAP-1 AND IL-23R AS A LEADING GENETIC PREDICTORS OF DEVELOPMENT OF ANKYLOSING SPONDYLOARTHRITIS
Masuda Kasimova11 PhD, associate professor of Department of Internal Diseases №2 and Endocrinology of Tashkent Medical Academy of UzbekistanNigora Akhmedova22 PhD, associate professor of Department of Internal Diseases №2 and Endocrinology of Tashkent Medical Academy of Uzbekistan 3Khulkar Makhamatkhodjayeva33 Assistant of Department of Internal Diseases №2 and Endocrinology of Tashkent Medical Academy of UzbekistanZafar Sharapov44 Assistant of Department of Internal Diseases №2 and Endocrinology of Tashkent Medical Academy of UzbekistanAlibek Khudaynazarov55 Assistant of Department of Internal Diseases №2 and Endocrinology of Tashkent Medical Academy of UzbekistanShoira Kodirova66 PhD, associate professor of Department of faculty and hospital therapy №2 of Tashkent Medical Academy of Uzbekistan
ABI
Abstract
Abstract. A review of the genetic aspects of ankylosing spondylitis (AS), a chronic inflammatory disease of autoimmune origin with a predominant lesion of the axial skeleton is presented. Since the beginning of the era of the genome-wide search for associations, more than 150 loci associated with AS have been identified, but this explains no more than 30% of cases of inheritance. The review attempts to understand the role of the ERAP1 genes in the development of AS. Continuation of research in this direction will create the prerequisites for the emergence of new goals for targeted therapy.
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