PROLONGED SUBDEPRESSION FOR A LONG TIME EFFECTIVE TREATMENT DETECTION ALGORITHM
Abstract
Abstract. To date, timely diagnosis, differentiation, and effective treatment of its variants for prolonged sub depressive (dysthymic) disorders are important. This allows dysthymic disorder to choose the most rational treatment to relieve symptoms; otherwise, attempts to conduct treatment in patients will usually be ineffective. In the scientific literature, the psychopathological landscape of dysthymia is sufficiently widely covered, but the effective optogenetic treatment of various variants of this disorder has not been sufficiently studied, so this dysthymic pathology is of interest to many researchers working on the same topic. Dysthymia is a chronic subdepressive condition, a mental illness that leads people to social decadence. The term" dysthymia " was first introduced to psychiatry by K.Kalbaum introduced it in 1869 year to identify chronic forms of melancholia, in reverse to cyclotymia in which maniacal phases are not observed. Dysthymia is considered a protracted subdepression, in which the symptoms to diagnose "depression" in cases will not be etralized, but will be chronic (the duration of the disease will not be less than 2 years).\n\nDysthymia is often characterized by a beginning in adolescence, but is also observed in middle and involutional age. In the last decades, dysthymic disorders have become of great importance both scientifically and practically. This condition is associated with a wide prevalence of subdepression. According to BJSS (2018 y.) with dysthymic disorders, the incidence of the population is 3-6%. Dysthymia has a serious negative effect on the quality of life of patients, even in the absence of a concussion of mental activity. At present, it is observed that the violation of serotoninergic neurotoxicity plays an important role in the occurrence of both depression and panic disorders. In terms of clinical expression, a high indicator of comorbidity corresponds to the comorbidity of panic disorders with chronic dysthymia, that is, panic disorders, generalized panic disorders, social phobias, posttraumatic stress disorders (F40-F41 - MKB-10). The frequency of these comorbid disorders is 75-80%. S. Focusing on the data of Pini and co-authors, generalized panic disorders were detected in 65,2% of patients with dysthymia. Effectively eliminates the symptoms of dysthymia and panic disorders with selektiv antidepressants (SIOZSN) – Duloxetine, milnosipran, venlafaxine, essitalopram, which inhibits the reabsorption of the latest serotonin and norepinephrine in the last generation. This data will soon show that the neurotransmitter plays a pathogenetic role in the mutual dysfunction of the system. The absolute importance of serotonin and norepinephrine levels in comorbid dysthymic-panic disorders. It is known that one of these neurotransmitter systems modulates the initiation activity of the elongation cascade by another. It should be noted that in the overwhelming majority of cases, panic disorders lead to manifestation of depressive disorders. Dysthymia and panic disorder comorbidities deepen both the clinical signs of dysthymia and the social degradation of patients. At the same time, this comorbidity increases the resistance to treatment. Chronic depression is most often observed in patients with somatic disease of comorbidities (mainly dysthymia) and in patients with Type 2 diabetes. The socio-economic and medical importance of dysthymia disease is explained by its widespread prevalence, predisposition to chronic recurrence, adverse effects on patients ' quality of life and health, numerous funding of treatment and rehabilitation therapies. Until now, several studies have been conducted on the coverage of the chronological sequence of comorbid panic, and depressive disorders, in most of these studies, dysthymic disorders were observed before panic disorders (Lampe L et al , 2003, Lenze E J et al, 2005). Therefore, questions about the legalities, clinical significance, interaction of this comorbid pathology remain unanswered. Diagnostic and prognostic significance, the basic constitutional characteristic of patients has not been studied until the end (Simutkin g. G. and et al, 2000). In dysthymia and panic disorder comorbidities, the quality of life of patients is lower than that of one of these disorders (Gorman J M, 1996 , Lochner S et al, 2003). In addition , the treatment of dysthymic and panic disorders comorbidity is complicated (Hirschfeld R M, 2001 , Brown S et al, 2005). When dysthymic disorders are combined with panic disorders, it is urgent to study the clinical-dynamic characteristics of these comorbid pathologies, the importance of the main constitutional characteristics of patients, their social adherence and the effectiveness of selenium antidepressants.