THE EFFECT OF ENDOTOXICOSIS AND ENDOGENOUS INTOXICATION SYNDROME ON THE FUNCTIONAL STATE OF THE LIVER IN PATIENTS WITH DIABETES MELLITUS COMPLICATED BY THE DIABETIC FOOT SYNDROME
Abstract
Abstract: Objective: to study the effect of endogenous intoxication on the liver in patients\nwith diabetes mellitus (DM) complicated by purulent - necrotic soft tissue lesion (PNSFL).\nMaterials and methods: 110 patients with diabetes mellitus complicated by purulentnecrotic soft tissue lesion and the effect of endotoxicosis on the functional state of the liver\nwere examined in the intensive care unit, with optimization of correction of liver failure.\nPatients were divided into 2 groups: 52 (control), 58 (study), which, in addition to\ntraditional therapy, included hepatoprotectors and drugs that stop transaminase activity.\nConclusions. The inclusion of hepatoprotectors, antioxidants and drugs blocking transaminase\nactivity in complex therapy is pathogenetically justified and optimizes the outcomes of such\na formidable complication of diabetes as PNSFL.\nKeywords: endotoxicosis, endotoxemia, intoxication, diabetes mellitus, liver.\n