A METHOD FOR INCREASING THE EFFECTIVENESS OF CHON-DROPROTECTIVE THERAPY IN PATIENTS WITH TMJ ARTHRITIS-ARTHROSIS ACCOMPANYING CERVICAL OSTEOCHONDROSIS.
Abstract
Relevance. Many scientists dealing with the problem of spinal osteochondrosis (SO) believe that one of the most important factors that predetermine the trend towards chronicity of the main clinical syndrome - pain syndrome in lumbar osteochondrosis (LO) is the progression of the main pathogenetic element - catabolic metabolism in the affected interstitial space ringing disk – MTD [1-22]. Based on this, in order to restore the destroyed part of the affected IVD, chondroprotective drugs are used in the complex of conservative therapy for osteochondrosis of the spine [3-7, 9-12]. According to these factors, under the influence of chondroprotective drugs in the cartilaginous tissue of the affected IVD, protein synthesis from amino acids and mucopolysaccharide (glucosaaminoglucans, chondroitin sulfate) from monosaccharides is restored, with a simultaneous increase in their expression from chondrocytes into the matrix, where the self-assembly of the IVD macromolecule, aggrecan, is enhanced [1-25].