FEATURES OF THE OCCURRENCE OF SINGLE-NUCLEOTIDE POLYMORPHISM IL10 (C592A) AMONG PATIENTS WITH PURULENT-INFLAMMATORY DISEASES OF THE MIDDLE EAR AND ASSESSMENT OF ITS CONTRIBUTION TO THE MECHANISMS OF DISEASE FORMATION
Abstract
Abstract: The features of the single-nucleotide polymorphism of the IL10 (C592A) gene in purulent-inflammatory diseases of the middle ear were investigated. The polymorphism of the IL10 (C592A) gene was evaluated by analyzing DNA samples by setting up a polymerase chain reaction (PCR) in Real Time mode.\n\nTheresults of the study on the characteristics of the polymorphism of the IL10 (C592A) gene showed that it was revealed that the minor A allele can contribute to the initiation of inflammatory processes that realize the onset of purulent-inflammatory diseases of the middle ear, increasing the risk of their development as a whole by 1.6 times (χ2 = 2.5; P = 0.2). Moreover, the association became apparent. minor allele A (χ2 = 4.3; P = 0.05) with an increased risk of onset of mild course of purulent-inflammatory diseases of the middle ear. In addition, there was a tendency to increase the risk of formation of a mild course of the disease on the part of all three genotypes (C / C - χ2 = 3.2, P = 0.1; A / G - χ 2 = 1.3, P = 0.3; OR = 1.7; A / A - χ2 = 1.9, P = 0.2) of the polymorphic gene IL10 (C592A). Meanwhile, there are no significant associative relationships between the carriage of minor alleles A (χ2 = 0.5; P = 1.0), as well as genotypes C / A (χ2 = 0.2; P = 0.7) and A / A (χ2 = 0.2; P = 0.7) of the polymorphic il10 (C592A) gene and the development of purulent-inflammatory diseases of the middle ear of medium and severe course.