The role of SARS-CoV-2 in microcirculation disorders as one of the links in pathogenesis in diseases of the oral cavity and its treatment.
Kamilov X.PHead of the Department of Hospital Therapeutic Dentistry of the Tashkent State Dental Institute, Professor, DcS Kamilov K.PRakhimova M.A.Doctoral student of the Department of Hospital Therapeutic Dentistry of the Tashkent State Dental Institute Rakhimova M.A
ABI
Abstract
SARS-CoV-2 affects every system in our body in one way or another. Clinical manifestations of functional insufficiency of internal organs are accompanied by an increase in the level of inflammatory cytokines, in particular, interleukin 6 (IL-6), which plays a key role in the development of a cytokine storm. IL-6 mediates a wide range of inflammatory changes that cause disturbances in the structural and functional organization of blood vessels [1]. Patients infected with SARS-CoV-2 have an elevated serum level of IL-1β [4]. This cytokine is an indicator of cellular pyroptosis and may enhance the cellular pyroptosis cascade in lymphocytes, macrophages, and vascular endothelium, leading to vasculopathies in patients with COVID-19 [6, 7].
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