Relevance and prospects of application of cellular technologies in the treatment of acute pancreatitis
Abstract
Mesenchymal stem cells are a promising and innovative treatment for pancreatitis by suppressing inflammation.Significant clinical experience has been accumulated in the use of stem cells in the treatment of pancreatic lesions.The regenerative effect of stem cells introduced into the bloodstream or locally in diseases of the digestivetract is due to the paracrine effect - stimulation of regenerative processes due to the release of numerousgrowth factors and the possibility of transdifferentiation. The therapeutic effect of the use of mesenchymalstem cells in the treatment of pancreatic diseases is accompanied by a pronounced immunosuppressive effect.The possibilities and prospects of using stem cells, in particular mesenchymal cells in the treatment of acutepancreatitis and pancreonecrosis are shown.