FEATURES OF THE CLINICAL CURRENT AND DIAGNOSTICS MUSCULO - SKELETAL COMPLICATIONS OF ACROMEGALY
Kholova Dilorom SharifovnaRepublican specialized scientific and practical Endocrinology Medical Center named after Academician Y.X. Turakulov, TashkentSafarova Shoxsanam MasharipovnaRepublican specialized scientific and practical Endocrinology Medical Center named after Academician Y.X. Turakulov, TashkentPulatova Mekhriniso BakhodirovnaRepublican specialized scientific and practical Endocrinology Medical Center named after Academician Y.X. Turakulov, TashkentIssaeva Saodat SaidullaevnaRepublican specialized scientific and practical Endocrinology Medical Center named after Academician Y.X. Turakulov, TashkentMirsaidova Umida AkmalevnaRepublican specialized scientific and practical Endocrinology Medical Center named after Academician Y.X. Turakulov, Tashkent
ABI
Abstract
Abstract: Acromegaly is one of the chronic endocrinopathies, which is based on hypersecretion of growth hormone (GH) and, accordingly, insulin-like growth factor 1 (IGF-1) by a pituitary tumor. Human GH and the main mediator of its stimulation effects, IGF-1, play an important role in the regulation of bone tissue metabolism. It is known that although GH deficiency in adults contributes to the phenomenon of bone loss and the development of osteoporosis, the effect of excess GH on bone health is still unclear.
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