Anti-ulcer effect of megosin in a model of acute experimental colitis in RATS
Mamatmusaeva Nilufar ErkinovnaPhD student, senior researcher, Tashkent Pharmaceutical InstituteAbdugafurova Dilnoza GulamovnaSenior researcher Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of UzbekistanVypova Natalya Leonidovnaleading researcher Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of UzbekistanZiyaev Khayrulla Lutfullaevichleading researcherInstitute of Bioorganic Chemistry of the Academy of Sciences of the Republic of UzbekistanTagayalieva Nigora Abdunabievnasenior researcher Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of UzbekistanAbrekova Nadjie NarimanovnaJunior researcher Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of UzbekistanSagdullaev Bakhodir TakhirovichLeading researcher Institute of Bioorganic Chemistry of the Academy of Sciences of the Republic of Uzbekistan
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Abstract
Megosin is the original derivative of gossypol. Previously, the drug was obtained by condensation of gossypol with β-aminoethylsulfate sodium and used as an immunosuppressive agent, which was a low-toxic substance and contributed to a longer engraftment of skin flaps in mice, kidneys and lungs in dogs. Further, it was used as an antiherpetic agent, in the form of a 3% ointment. At present, the Institute of Bioorganic Chemistry, on the basis of existing dosage forms, has developed megosin enteric capsules for the treatment of ulcerative colitis and conducted histological studies, which proved the ulcer-healing effect of the new dosage form of megosin.
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