The Role of The Polymorphic Version of C/G Gene Il 17 on The Mechanism of Development of Genital Prolapse after Hysterectomy in Women of The Uzbek Population
Abstract
Recent reports of genital prolapse in nulliparous women, as well as in women after caesarean section, indicate a constitutional factor and a genetic predisposition in the development of this pathology.In this regard, it is important to assess risk factors, as well as preclinical signs of genital prolapse in women of both childbearing and perimenopausal age.For this contingent of women, the choice of optimal treatment strategy is based on determining the 121 women aged 26 to 64 years.Among 121 patients, the main group consisted of 91 (75.2%) women with GPGE, and the control group consisted of 30 healthy women without GP (Figure 1). SummaryThe article presents the results of the molecular genetic studies of the IL-17 gene in women with the post hysterectomy prolapse of the genitalia.121 women aged 26 to 64 years were examined.The results of the study showed that the Getero C/G Homozygote genotypes allele and the IL-17 Polymorphism are significant markers of increased risk of GPAHE development in women of working age in the Uzbek population.(P<0.05).(χ2 = 110.5;p<0; R = 2086.2;95% CI 97.3-44734.03)Allele C and functionally favorable C/C genotype are reliable protective markers in relation to the development of pathology (χ2 = 35, 53; p <0.