STUDY OF THE INFLUENCE OF THE DIURETIC PREPARATION “ECUSTIM” ON THE ELECTROLYTE BALANCE AND THE LEVEL OF CREATININE AND UREA IN THE URINE
Abstract
The article presents the results of studying the effect of the drug “Ecustim” on the electrolyte balance and the level of creatinine and urea in the urine. The diuretic activity of the drug “Ecustim” was studied on 24 white rats weighing 125-140 g. The volume of excreted urine was measured, and the concentration of potassium and sodium ions was determined by spectrometry on the ICP-MS spectrometer “Nexion-2000” USA. The drug “Ecustim” administered once intragastrically at a dose of 100 mg/kg, for 8 hours of observation increases diuresis 2.5 times more. With the introduction of the drug at a dose of 150 mg/kg, diuresis increases by 3.1 times, respectively. The experiment also determined the content of urea and creatinine in the urine. The drug “Ecustim” at a dose of 100 mg / kg stimulates the excretion of urea by 1.5 times and the excretion of creatinine by 1.4 times more than in the control group.