VASCULAR ENDOTHELIAL DYSFUNCTIONS WITH HYPERLIPOPROTEINEMIA
Abstract
<strong><em>Relevance</em></strong><em>. </em> <em>Cardiovascular diseases and, primarily coronary heart disease, remain among the leading causes of disability and mortality worldwide.</em> <strong><em>А</em></strong><strong><em>im. </em></strong><em>To study the relationship between vascular endothelial dysfunction and hyperlipoproteinemia in experimental atherosclerosis.</em> <strong><em>Materials and methods. </em></strong><em>The experiments were carried out on 28 Chinchilla rabbits with an average weight of 2.5-3.0 kg. The action of drugs was studied in dynamics: the initial 3-month condition and after one month of drug administration. The results obtained were compared with those of the control and intact groups.</em> <strong><em>Results. </em></strong><em>Long-term administration of cholesterol is accompanied by the development of hypertriglyceridemia, the severity of which depends on the duration of the experiment.</em> <strong><em>Conclusion. </em></strong><em>An important role in the development of endothelial dysfunction in hypercholesterolemia is played by a decrease in the synthesis of endothelial nitric oxide and an increase in its active radicals, causing modification of low-density lipoproteins and their deposition in the vascular endothelium.</em>