RELATIONSHIP BETWEEN THE AUTONOMIC SYSTEM AND RHEUMATOID ARTHRITIS
Abstract
Neuronal stimulation is a new area of research aimed at the management and treatment of various diseases by restoring physiological homeostasis. Electrical vagus nerve stimulation has recently been proposed as a revolutionary treatment option for rheumatoid arthritis (RA) in combination with conventional and biological treatments, or even as a replacement. In the past few years, disruption of the autonomic system has been associated with the onset and activity of RA. New research into the relationship between the autonomic nervous system and the immune system (immuno-autonomy) has paved the way for the development of innovative treatment strategies for rheumatoid arthritis. Clinical data support this approach. Cardiovascular involvement in the form of decreased baroreflex sensitivity and indices derived from heart rate variability, as well as mood disorders, common comorbidities in RA patients, has been associated with autonomic nervous system dysfunction, which in turn is affected by increased levels of circulating pro-inflammatory substances. cytokines. This descriptive review provides an overview of the autonomic nervous system and association with RA, discusses most of the common heart and mental health comorbidities associated with RA, and their potential association with systemic and joint inflammation.