DEKSKETOPROFEN TRAMETAMOL CAPSULE DRUG FORM COMPOSITION SELECTION AND TECHNOLOGY DEVELOPMENT
Abstract
Previous research has investigated the technological properties of the dexketoprofen trametamol substance and has been shown to be negative. For this reason, the article covers research on the selection, technology development of a complex of various auxiliary substances for the development of a capsule drug form based on the substance dexketoprofen trametamol. In it, the size of the capsule was determined on scientific basis, based on the scattering density of the substance, and encapsulated masses were prepared using various excipients. As a result of determining the technological properties of these compositions as well as the quality indicators of the capsules obtained, the optimal compositionwas selected and the capsule technology was developed, in which the dexketoprofen trametamol substance was stored.