Tuberculous Pleurisy: the role of the ADA Enzyme in Diagnosis and Treatment Outcomes
Fazlkhan Abdugapparov1Department of Phthisiology and Pulmonology of the Tashkent medical academy, Republic of Uzbekistan, Tashkent region, Chirchik city, Ibn SinoLochin Mamatov2Department of Phthisiology and Pulmonology of the Tashkent medical academy, Republic of Uzbekistan, Tashkent city, Mirabad district, TallimarjonDauranbek Ongarbayev3Department of Phthisiology and Pulmonology of the Tashkent medical academy, Republic of Uzbekistan, Tashkent city, Almazar district, Tansiqbayev
ABI
Abstract
Extrapulmonary TB, representing nearly 15% of the global TB burden, is more difficult to diagnose. Tuberculous pleural effusion (TPE), one of the commonest forms of extrapulmonary TB, is a diagnostic challenge with rather poor microbiologic confirmation rates from pleural fluid analysis2,3. Even diagnostic tools like CBNAAT and interferon-gamma release assays have shown suboptimal diagnostic accuracy4,5. Adenosine deaminase (ADA), an enzyme produced from lymphocytes and involved in purine metabolism, has been extensively studied as a biochemical marker in pleural fluid during investigation for TPE. The test is simple, cheap, rapid, minimally invasive, and can be performed in most laboratories3.
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