EPIGENETIC INACTIVATION OF TUMOR SUPPRESSOR GENES- MARKER FOR MONITORING THE EFFECTIVENESS OF THERAPY
Dilbar Abdullaevna KadirovaInstitute of Biophysics and Biochemistry at the National University of the Republic of UzbekistanN.SH. AVEZOVInstitute of Bioorganic Chemistry named after Obid Sodiqov Academy of Sciences of the Republic of UzbekistanА. А. ИбрагимовTASHKENT RESEARCH INSTITUTE OF VACCINES AND SERUMA.N. MAKSUDOVATashkent Pharmaceutical Institute
ABI
Abstract
Epigenetic inactivation of tumor suppressor genes caused by hypermethylation of the promoter area is as characteristic of the tumor process as genetic disorders, serving as an alternative mechanism of the function loss by the tumor suppressor genes. An analysis of the promoter area of RARв2 gene-suppressors has been performed in the normal condition and in breast cancer by methyl-sensitive polymerase chain reaction. Methylation of CpG-dinucleotides in the RARв2 gene promoter area was demonstrated. Abnormal methylation of the RARв2 gene promoter area may be used as a marker for early diagnosis and monitoring of the treatment efficacy in patients with the breast cancer.
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