HYPERURICEMIA AND ITS RELATIONSHIP WITH METABOLIC DISORDERS IN HYPERTENSIVE PATIENTS
Abstract
Objective: To study the prevalence of hyperuricemia and its role in the development of metabolic disorders in hypertensive patients. Design and method: We analyzed 188 hypertensive patients. 109 were female and 79 were male, for a mean age of 62.8±10.2 years. Uric acid, glucose, creatinine, and blood lipids were determined using the RANDOX Daytona autoanalyzer (UK). Microalbuminuria (MAU) in the morning urine was determined using a quantitative enzymatic method. Hyperuricemia was established when the level of uric acid was >7 mg/dl in men and >5.7 mg/dl in women. Statistical analysis was conducted using SPSS 24.0. Results: Patients were divided into two groups: the first group consisted of patients with hyperuricemia (n = 103), and the second group consisted of patients with normal levels of uric acid (n = 85). The average level of uric acid in the 1st group was 7.44±1.33 mg/dl, and in the 2nd group, it was 5.06±0.98 mg/dl, p<0.00001. The compared groups were comparable in terms of age, office SBP, and DBP. Body mass index (BMI) and waist circumference (WC) also did not differ between groups: BMI-32.96±5.84 kg/m2 vs 31.24±5.00 kg/m2, p = 0.44; OT-105.44±13.75 cm vs 102.76±12.06 cm, p =0.16. Patients with hyperuricemia had a significantly higher level of MAU: 63.24±104.06 vs. 39.33±36.42 mg/l, p = 0.044. Patients with hyperuricemia had more pronounced dyslipidemia. Thus, total cholesterol was significantly high in group 1: 198.31±49.41 mg/dl vs. 181.75±49.1 mg/dl, p = 0.04, and LDL-C was 111.83±42.46 mg/dl vs. 100.56±37.99 mg/dl, p = 0.04. TG and HDL-C did not differ between the groups. TG: 223.39±130.76 vs. 189.69±122.18, p = 0.057. HDL-C: 41.92±13.54 mg/dl vs. 43.30±12.87 mg/dl, p = 0.48. Patients with hyperuricemia had a significantly high level of glucose compared with patients with normal levels of uric acid: 9.71±04.35 mmol/l vs. 6.51±3.06 mmol/l, p = 0.0001. The creatinine level was also high in patients with hyperuricemia: 98.45±36.75 μmol/l vs. 85.06±17.21 μmol/l, p = 0.003. Conclusions: Hyperuricemia should be considered as an additional cardiovascular risk factor in patients with hypertension. Hyperuricemia is associated with another metabolic disorders in hypertensive patients.