Study Of Indirect Fibromarkers inIdentifying theDegree ofLiver Fibrosis During Antiviral Therapy Of Patients With Hepatitis HCV Etiology
Praveen K. BhartiNandesh Mohan PKhikmatullaeva A.S.Research Institute of Virology of the Republican specialized scientific and practical medical center of epidemiology, microbiology, infectious and parasitic diseasesAbdukadirova M.A.Yu. Balanova A.Reham ShResearch Institute of Virology of the Republican specialized scientific and practical medical center of epidemiology, microbiology, infectious and parasitic diseasesJohn S. YuResearch Institute of Virology of the Republican specialized scientific and practical medical center of epidemiology, microbiology, infectious and parasitic diseasesIbadullaeva N.S.Mirrakhimova N.MResearch Institute of Virology of the Republican specialized scientific and practical medical center of epidemiology, microbiology, infectious and parasitic diseasesKavitha CH NResearch Institute of Virology of the Republican specialized scientific and practical medical center of epidemiology, microbiology, infectious and parasitic diseasesMatyakubova Feruza EgamovnaSamarkand State Medical University
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Abstract
This work examined the diagnostic role of biomarkers -APRI, alpha-fetoprotein–AFP and gammaglutamine transpeptidase–GGTP before and after antiviral therapy in patients with different degrees of liver fibrosis. At the same time, there was a decrease in these indicators after treatment, which indicates a reverse development of liver fibrosis after specific therapy.During therapy, a significant decrease in APRI from 0.67 to 0.33 (p<0.05), AFP from 4.82 to 1.77 (p<0.01) and GGTP from 42.4 to 26.8 was established (p<0.05). Thus, APRI, AFP and GGTP indicators can be used as dynamic markers for assessing the antifibroticeffect of etiotropic therapy for hepatitis C
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