Hypomethylation of the p53 and p16 suppressor genes in cellular aging
Dilbar A. KadirovaInstitute of Biophysics And Biochemistry at the National University of Uzbekistan Named after M.Ulugbek in Tashkent, UzbekistanP. MirhamidovaTashkent State Pedagogical University named after Nizami, Tashkent, UzbekistanGulnara ShakhmurovaTashkent State Pedagogical University named after Nizami, Tashkent, UzbekistanRano AlimovaTashkent State Agrarian University, Tashkent, Uzbekistan
ABI
Abstract
Protein p53, a product of p53 gene expression, protects the integrity of the genome throughout life and promotes the cell repair in the process of cell aging. In this review, the fundamental significance of the p53 gene was analyzed in the cell aging. The review showed that hypomethylation of the promoter region of the p53 and p16 suppressor genes occurs during aging; the DNA hypomethylation is explained by the possible age-related decrease in the content of CH3-groups donor (S-adenosyl monophosphate) in the cell, and by the activity of DNA methyltransferases.
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