Omparative description of frequencies of determination of alleles and genotypes of gene polymorphisms in patients with acute sensoneural hearing loss
Abstract
Our data confirm the complexity of the genetic mechanism of the development of ASNHL in patients with acute sensorineural hearing loss of vascular genesis and demonstrate the need and importance of understanding the complex interaction of genes in analyzing the development and clinical stage of the pathology under study. By analyzing the distribution of genotypic variants of this polymorphism, we determined that the C-634G rs2010963 polymorphism in the VEGF-A gene is associated with the development of ASNHL of the G/G monogenotype. In group 1 of patients with vascular ASNHL, a tendency for an increase in the frequency of the minor genotype of the C-634G rs2010963 polymorphism in the VEGF-A gene (χ2=4.6; P=0.30; RR=2.15; OR=1.1; 95%CI: 2.174-6.69) was observed in comparison with the control group. In this case, the indicators of patients in group 1 were separated and compared with the control group, and the OR and RR indicators increased, and the level of reliability in the G/G genotypes increased significantly (χ2 =0.39; P=0.29; RR=2.35; OR=2.4; 95% CI: 37.929- 36.50).