INHIBIN A AS A PREDICTOR OF RECURRENT PREGNANCY LOSS IN WOMEN WITH HYPERPROLACTINEMIA
Abstract
Background. Recurrent pregnancy loss (RPL) remains a significant challenge in obstetric practice, impacting the physical and psychological well-being of affected women. Hyperprolactinemia, a common endocrine disorder among women of reproductive age, is associated with an increased risk of early pregnancy loss. Research Objective. To evaluate inhibin A as a biomarker for predicting recurrent pregnancy loss in women suffering from hyperprolactinemia and to highlight its diagnostic significance in early gestation. The article presents a comprehensive review of clinical and experimental findings related to inhibin A secretion dynamics, its role in endocrine regulation, and its diagnostic relevance in early pregnancy complications. The relationship between hyperprolactinemia and impairments in endometrial receptivity, luteal phase function, and hormonal support of early pregnancy is discussed in detail. Additionally, comparative analyses of inhibin A levels in normal versus complicated pregnancies are examined, with attention to its fluctuations across gestational trimesters.