Article

Analysis of anti-tumor active components and preparation of self-assembled polymeric micelles in <i>taxus chinensis</i> seeds

Qilong WangDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityXiaowen WangDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityXia JiangDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityQinyang HuaDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityMichael Adu‐FrimpongDepartment of Biochemistry and Forensic Sciences, School Chemical and Biochemical Sciences, C. K. Tedam University of Technology and Applied Sciences (CKT-UTAS)Mingjie GongDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityTingyuan LiDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityJiaying LiDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityElmurat ToreniyazovInstitute of Agriculture and Agrotechnologies of KarakalpakstanJollibekov BerdiyarInstitute of Agriculture and Agrotechnologies of KarakalpakstanXia CaoDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityJiangnan YuDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu UniversityXiming XuDepartment of Pharmaceutics, School of Pharmacy, Center for Nano Drug/Gene Delivery and Tissue Engineering, Jiangsu Provincial Research Center for Medicinal Function Development of New Food Resources, Jiangsu University

Drug Development and Industrial Pharmacyjournal2025en

ABI

Abstract

OBJECTIVE: seeds, which was combined with TPGS and mPEG-PCL to make micelles, improve its solubility and anti-tumor activity, and reduce the toxic side effects. METHODS: solvent injection combined with TPGS and mPEG-PCL and optimized using the single-factor screening experiment. RESULTS: BE-M were spherical micelles with particle size (34.37 ± 0.11) nm and polydispersity index (PDI) 0.152 ± 0. 003, possessing a high encapsulation rate (86.53 ± 1.54) % and drug loading (21.63 ± 0.87) %. The critical micelle concentration (CMC) value was very low at 0.881 μg/mL, indicating that BE-M has good stability. X-ray diffraction analysis (XRD) and Fourier transform infrared analysis (FT-IR) showed that BE had been successfully encapsulated in BE-M. CONCLUSION: anti-tumor effect of BE.

Topics

Surfactants and Colloidal Systems Nanoparticle-Based Drug Delivery Biological Activity of Diterpenoids and Biflavonoids

Identifiers

DOI: 10.1080/03639045.2025.2535508

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