Association between dietary amino acids ratio with metabolic profile and C-Peptide levels among overweight individuals
Abstract
BACKGROUND: . This condition can arise from various factors, including poor dietary choices, sedentary lifestyles, genetic predispositions, and environmental influences. The impact of dietary amino acids on metabolic health remains a topic of debate. In this study, we explored the correlation between the ratio of dietary branched-chain amino acids (BCAAs) to aromatic amino acids (AAAs) and metabolic profiles, including C-Peptide levels in overweight individuals. METHODS: A total of 221 overweight participants were enrolled in this study. Dietary intake was assessed using a validated food frequency questionnaire (FFQ). We conducted laboratory tests to measure metabolic variables, lipid profiles, glycemic indicators, and C-Peptide levels. RESULTS: Participants in the highest tertile of the dietary BCAAs/AAAs ratio exhibited significantly lower blood sugar levels and higher concentrations of high-density lipoprotein (HDL) compared to those in the lowest tertiles, with p-values of 0.033 and 0.003, respectively. CONCLUSION: Our findings suggest that a higher dietary ratio of BCAAs to AAAs is linked to improved metabolic health among overweight individuals. However, further longitudinal studies are necessary to clarify the causal relationships between these dietary factors and metabolic outcomes. CLINICAL TRIAL NUMBER: Not applicable.