ANALYSIS OF CTLA-4 GENE POLYMORPHISMS IN TYPE 1 DIABETES MELLITUS
Abstract
Type 1 Diabetes (T1D) is a chronic autoimmune disease that results from the destruction of insulin-producing pancreatic β-cells by the body's own immune system. The development of the disease is significantly influenced by both genetic and environmental factors. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays a critical regulatory role in the immune system and serves as a decisive factor in the pathogenesis of T1D. This article analyzes the impact of CTLA-4 gene polymorphisms on the development of T1D. The purpose of this article is to provide a comprehensive analysis of the role and clinical significance of CTLA-4 gene polymorphisms in the pathogenesis of Type 1 Diabetes, as well as to study the characteristics of this association across different ethnic groups.