Laboratory And Clinical Correlates Of Early Metabolic Syndrome In Young Adults
Abstract
Metabolic syndrome (MS) is increasingly diagnosed among young adults, representing a multifactorial condition that combines metabolic, cardiovascular, and inflammatory disturbances. This study aimed to investigate the laboratory and clinical parameters of young patients with MS, emphasizing early biomarkers associated with metabolic dysregulation and vascular dysfunction. A total of young participants aged 20–40 years with clinically verified MS were examined using biochemical, hemodynamic, and anthropometric indicators. The analysis revealed a significant correlation between elevated fasting glucose, triglycerides, low-density lipoprotein (LDL) cholesterol, and reduced high-density lipoprotein (HDL) levels. High-sensitivity C-reactive protein (hs-CRP) and fibrinogen were elevated, reflecting chronic low-grade inflammation. Insulin resistance indices (HOMA-IR) demonstrated strong associations with body mass index (BMI) and systolic blood pressure, suggesting the contribution of endothelial dysfunction to the early pathogenesis of MS. The findings indicate that even in the early stages of metabolic syndrome, laboratory markers can serve as sensitive predictors of cardiovascular and neurovascular risk, underscoring the need for timely preventive strategies in young populations.