IMPACT OF MUMIJO (SHILAJIT) ON BLOOD COAGULATION PARAMETERS IN CHRONIC DOG EXPERIMENTS
Abstract
The present study investigated the effects of chronic administration of mumiyo at a dose of 100 mg/kg on the blood coagulation system in dogs. Five healthy adult animals were monitored over six days, and coagulation parameters were assessed at baseline and on days 3, 5, and 6. Mumiyo administration produced a significant prolongation of blood clotting time, plasma recalcification time, thrombin time, and heparin time, indicating a marked reduction in overall coagulation activity. Plasma tolerance to heparin increased progressively, suggesting enhanced sensitivity to anticoagulant modulation. Coagulation factors II and V exhibited time-dependent changes, with Factor II increasing steadily and Factor V showing an initial decrease followed by significant elevation. Fibrinogen levels increased moderately, while fibrinolytic activity decreased, reflecting slower clot degradation. Collectively, these findings demonstrate that mumiyo shifts hemostasis toward a hypocoagulable state and promotes the formation of looser, less stable clots. The results suggest potential anticoagulant properties of mumiyo and support the need for further studies to elucidate its mechanisms of action and therapeutic applicability.