Article

TUMOR-ASSOCIATED MACROPHAGES (TAMS) AND THEIR BIOLOGICAL FUNCTIONS

Zafar Abdujalilovich MamajonovAndijan State Medical InstituteGulrukhan J. Ulug’bekovaAndijan State Medical InstituteIroda Yu. MamatovaAndijan State Medical Institute

Journal of Chemistry of Goods and Traditional Medicinejournal2025

ABI

Abstract

Tumor-associated macrophages (TAMs) are one of the most abundant immune cell populations in the tumor microenvironment (TME). By interacting with tumor and stromal cells, TAMs promote angiogenesis, suppress adaptive immunity, and facilitate metastasis. Most TAMs resemble the M2-like phenotype, secreting immunosuppressive and pro-tumorigenic factors such as IL-10, TGF-β, and VEGF. Their functional reprogramming has been recognized as a promising target in cancer immunotherapy.

Topics

Immune cells in cancer Phagocytosis and Immune Regulation Immune responses and vaccinations

Identifiers

DOI: 10.55475/jcgtm/vol4.iss5.2025.538

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