Article

Effect of Polyphenols on the Hemostatic System in Rats with Streptozotocin-Induced Type II Diabetes

Guli M. Raimova1Department of Electrophysiology, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanSiroj Khodjiyev1Department of Electrophysiology, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanKabil E. Nasirov1Department of Electrophysiology, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanNozim Khoshimov1Department of Electrophysiology, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanMukhamatkodir Ortikov1Department of Electrophysiology, Institute of Biophysics and Biochemistry, National University of Uzbekistan, Tashkent, UzbekistanAlisher A. Mukhtorov3Department of Human and Animal Physiology, Nаtiоnаl Univеrsitу оf Uzbеkistаn named after M. Ulugbek,Tashkent, UzbekistanRustam Makhmudov2Department of Protein and Peptide Chemistry, Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, UzbekistanGaуbullo Lutpillaеv2Department of Protein and Peptide Chemistry, Institute of Bioorganic Chemistry, Academy of Sciences of the Republic of Uzbekistan, Tashkent, UzbekistanZamira Teshabayeva4Department of Pedagogical of preschool education of Chirchik State Pedagogical University, Chirchik, UzbekistanRano Khamidovna Nosirova4Department of Pedagogical of preschool education of Chirchik State Pedagogical University, Chirchik, UzbekistanZulfizar Tuychiyeva4Department of Pedagogical of preschool education of Chirchik State Pedagogical University, Chirchik, UzbekistanSabina Normurodova4Department of Pedagogical of preschool education of Chirchik State Pedagogical University, Chirchik, UzbekistanAkbarova Gulbakhor5Department of Pedagogical University named after Nizam, Tashkent State, Uzbekistan

Biomedical & Pharmacology Journaljournal2025

ABI

Abstract

In type 2 diabetes mellitus, all hemostatic systems involved in blood clotting, regulation of vascular tone, the condition of blood cells, and plasma enzyme systems are activated. In this disease, there is a clear correlation between hemocoagulation disorders and the degree of glycemia. In this regard, an important and urgent task is to study these mechanisms and to search for new drugs that can prevent further progression. In this study, experiments on model rats were conducted to test the effects of polyphenols as antidiabetic agents. Polyphenol-containing foods and beverages such as coffee, guava tea, blueberries, olive oil, propolis, chocolate, red wine, grape seeds, and cocoa have been shown to exert beneficial effects in individuals with type 2 diabetes mellitus. These compounds contribute to better glucose regulation, enhance vascular health, reduce insulin resistance, and help lower HbA1c levels, thereby potentially mitigating both the progression and complications of diabetes, including alterations in the hemostatic system. This paper presents a study of polyphenol preparations isolated from the Pistacia vera plant (compound ANK-1), the Karelinia caspia plant (compound KCL-1), and an extract from the Isatis tinctoria L. plant (compound ITL-2), and their effects on biochemical parameters and the blood-clotting system in rats with experimentally induced type 2 diabetes caused by streptozotocin.

Topics

Plant-Derived Bioactive Compounds Phytochemicals and Antioxidant Activities Natural Antidiabetic Agents Studies

Identifiers

DOI: 10.13005/bpj/3310

Citations and references

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