Investigation of Hepatoprotective and Antidepressant Activity of Oil Extracted from the Iceland Plant in Experimental Animals under Study Conditions
Abstract
The increased incidence of mental and emotional disorders against the background of ChLD, leading to disability and death due to its severe complications, in turn, leads to a further exacerbation of the existing problem. The high prevalence of depressive states in patients with ChLD compared with healthy people and the hepatotoxicity of existing antidepressants make it imperative to search for hepatoprotectors and antidepressants with a less toxic natural base. In this regard, the main purpose of the presented manuscript is to determine the hepatoprotective and antidepressant activity of the vegetable oil of Iceland in the study conditions. Studies to detect hepatoprotective activity were conducted on white rats and ChTLD was caused by oral administration of 500 mg/kg of pratacetamol and 1 ml of 40% ethanol for two weeks. On the other hand, the hepatoprotective activity of the test substance was assessed by blood biochemical parameters, the amount of bile secretion and its effect on its composition, and the antidepressant activity was realized in white mice using methods C. Hall, R. Porsolt and L. Steru. In the conducted studies, IVO was studied in doses of 100; 150 and 200 mg/kg, which showed high activity in stabilizing biochemical parameters disrupted by chronic administration of toxic substances, normalizing the excretion of bile and its components. It was found that the vegetable oil studied for this activity showed pronounced activity compared to the control dose and lower activity compared to the dose of phosphogliv 50 mg/kg, while apkosul showed similar activity compared to the dose of 100 mg/kg. In addition, the experimental animals showed clear depressive activity due to improved motor and search activity, increased forced swimming time and decreased immobilization time, and in terms of this activity, the comparative drug is not inferior to the studied dose of fluoxetine 10 mg/kg. The results obtained on the basis of research, in turn, dictate the need for large-scale physico-chemical studies based on this vegetable oil in order to obtain separately bioactive phytocomponents for the initial determination of their components. However, structural studies of this vegetable oil may lead to a further expansion of the range of PhTS.